Crystallochemistry laboratory

Chemistry Department, Warsaw University

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Dr Maria Górna

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Dr Maria Górna
Curriculum Vitae
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For the most up-to-date information about Maria and her Structural Biology Group, please visit our group webpage:

gorna.uw.edu.pl

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The Structural Biology Group is a young, dynamic team created at the launch of a new research institute, UW BCRC (CNBCh UW), in its brand new building at the heart of the Ochota Campus of the University of Warsaw.  We engage in medically-relevant research topics and use state-of-the art methods in biophysical characterization of proteins.The lab owns the latest equipment and facilities for protein expression and purification, SEC-MALS, DLS, MST, as well as crystallization robots (Mosquito LCP, Dragonfly), a plate hotel with UV imaging, access to home X-ray sources.

 


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Maria Górna, Ph.D.

Leader of the Structural Biology Group, University of Warsaw Biological and Chemical Research Centre

Structural Biology Group members:

  • Matthew Merski, Ph.D. (postdoctoral fellow)

  • Jan Kutner, Ph.D., Eng. (postdoctoral fellow, lab/facility manager)

  • Monika Kowalska, Ph.D., Eng. (postdoctoral fellow, R&D)

  • Marcin Ziemniak, Ph.D. (Postdoctoral fellow)

  • Joanna Boros-Majewska, D.Eng (postdoctoral fellow, R&D)

  • Krzysztof Młynarczyk, M.Sc. (PhD student in the BIOmodeling group of Prof. S. Filipek)

  • Natalia Karolak, M.Sc. (research technician)

  • Anna Laskowska, M. Sc. (research technician)

  • Jakub Skrzeczkowski (undergraduate student)

  • Mikołaj Kuska (undergraduate student)

  • Maja Czub, B.Sc. (undergraduate student, research technician)

We are always interested in qualified and highly motivated students and postdocs. Please contact me for further details.

 


Maria Górna, Ph.D. - Scientific profile: ResearchGate and Scopus

Scientific interest:

  • protein crystallography and SAXS

  • relationship between protein structure and function;

  • RNA binding proteins and RNA metabolism;

  • innate immunity and pathogen recognition;

  • oncogenic kinases;

  • diagnostic testing in human diseases

 

Hobby:

  • reading and languages,

  • all things creative;

  • water sports;

 

Contact:

  • phone: +48 22 55 26 685

  • e-mail: mgorna [at] chem.uw.edu.pl


Maria Górna, Ph.D. - Curriculum Vitae

Research positions and degrees

  • Since 2015 Leader of the Structural Biology Group, Biological and Chemical Research Centre, University of Warsaw;

  • Since 2015 Marie Skłodowska-Curie Actions Fellow (H2020), Faculty of Chemistry, University of Warsaw;

  • Since 2015 Assistant Professor (Adiunkt), Faculty of Chemistry, University of Warsaw;

  • 05-07.2015 Visiting researcher (EMBO ASTF), Membrane Protein Laboratory, Diamond Light Source, Harwell Science & Innovation Campus, UK;

  • 2010-2015 Postdoctoral Fellow, Giulio Superti-Furga group, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria;

  • 04-05.2010 Visiting collaborator, Stefan Knapp group, Structural Genomics Consortium, University of Oxford, UK

  • 2006-2010 PhD student in Biochemistry and Marie-Curie Early Stage Researcher (EU FP6), Ben Luisi group, Department of Biochemistry, University of Cambridge, UK;

  • 2002-2006 Master student in Biotechnology (and Theoretical Chemistry), College of Inter-faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Poland;

  • 2004/2005 Socrates-Erasmus exchange student, Georg-August Universitaet, Goettingen, Germany;

  • 2001-2004 Bachelor student in Biotechnology, Faculty of Biology, University of Warsaw;

Awards

  • 2017, Grant (Premia na Horyzoncie), Ministry of Science and Higher Education

  • 2017, EMBO Small Grant

  • 2015, EMBO Installation Grant

  • 2015, Grant LIDER VI, National Centre for Research and Development, Poland, #039/L-6/2014

           (ranked as #1 project related to biological sciences and #3 nation-wide across all disciplines)

  • 2015, Grant Sonata 8, National Science Centre, Poland, #2014/15/D/NZ1/00968 (ranked #1)

  • 2015, Marie Skłodowska-Curie Individual Fellowship, H2020 MSCA-EF-IF-2014, #655075

  • 2015, EMBO Advanced Short-Term Fellowship, #235-2015

  • 2015, 2016 Grant for young researchers (DSM), Faculty of Chemistry, University of Warsaw (ranked #1)

  • 2015, FEBS Journal Poster Prize, Conference "Multi-Pole Approach to Structural Science", Warsaw, PL

  • 2009, Clare Hall Bursary, University of Cambridge, UK

  • 2009, General Travel Grant and publication of a Traveller's Tale, The Biochemical Society, UK

  • 2008, Qiagen Poster Prize, Department of Biochemistry, University of Cambridge, UK

  • 2006, Honorary Scholar of Cambridge European Trust

  • 2006, Marie Curie Host Fellowship for Early Stage Researchers within ChemBioCam RTN (EU FP6), Department of Biochemistry, University of Cambridge, UK

  • 2006, BBSRC PhD studentship (declined in favour of the above)

  • 2004, 2005, 2006, Studentship of the Polish Minister of Science/Education for outstanding achievements in study

  • 2002-2007, annually, highest scientific stipends for the academic performance from the Faculty of Biology and from the College of Inter-faculty Individual Studies in Mathematics and Natural Sciences (MISMaP), University of Warsaw, Poland

Other activities

  • 2016, Chairwoman and co-founder of the Polish Chapter of Marie Curie Alumni Association

  • 2005/2006, President of the student Society of Genetics and Epigenetics (KNGiE) at the Faculty of Biology, University of Warsaw, Poland (2003/2004, co-founder and vice-president)


Our funding sources:

altalt   H2020-MSCA

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Maria Górna, Ph.D. - publication list:
  1. Byrgazov K, Kastner R, Gorna M, Hoermann G, Koenig M, Lucini CB, Ulreich R, Benesch M, Strenger V, Lackner H, Schwinger W, Sovinz P, Haas OA, van den Heuvel-Eibrink M, Niemeyer CM, Hantschel O, Valent P, Superti-Furga G, Urban C, Dworzak MN, Lion T (2017) NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia. 31(1):237-240.
  2. Dikoglu E, Alfaiz A, Gorna M, Bertola D, Chae JH, Cho TJ, Derbent M, Alanay Y, Guran T, Kim OH, Llerenar JC Jr, Yamamoto G, Superti-Furga G, Reymond A, Xenarios I, Stevenson B, Campos-Xavier B, Bonafé L, Superti-Furga A, Unger S (2015) Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome. Am J Med Genet A. 167(7):1501-9.
  3. Dölker N#, Górna MW#, Sutto L, Torralba AS, Superti-Furga G, Gervasio FL (2014) The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion. PLOS Comput Biol 10(10):e1003863.   
  4. Vladimer GI, Górna MW, Superti-Furga G (2014) IFITs: Emerging Roles As Key Anti-Viral Proteins. Front Immunol, 5:94.
  5. Bonafé L#, Liang J#, Górna MW#, Zhang Q, Ha-Vinh R, Campos-Xavier AB, Unger S, Beckmann J, Le Béchec A, Stevenson B, Giedion A, Liu X, Superti-Furga G, Wang W, Spahr A,Superti-Furga A (2014) MMP13 Mutations are the Cause of Recessive Metaphyseal Dysplasia, Spahr Type. Am J Med Genet A, 164:1175–9.
  6. Abbas YM, Pichlmair A#, Górna MW#, Superti-Furga G, Nagar B (2013) Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.  Nature 494:60-4.
  7. Unger S#, Górna MW#, Le Béchec A#, Do Vale-Pereira S, Bedeschi MF, Geiberger S, Grigelioniene G, Horemuzova E, Lalatta F, Lausch E, Magnani C, Nampoothiri S, Nishimura G, Petrella D, Rojas-Ringeling F, Utsunomiya A, Zabel B, Pradervand S, Harshman K, Campos-Xavier B, Bonafé L, Superti-Furga G, Stevenson B, Superti-Furga A (2013) FAM111A Mutations Result in Hypoparathyroidism and Impaired Skeletal Development. Am J Hum Genet 92:990-5.
  8. Bandyra KJ, Said N, Pfeiffer V, Górna MW, Vogel J, Luisi BF (2012) The seed region of a small RNA drives the controlled destruction of the target mRNA by the endoribonuclease RNase E. Mol Cell 47:943-53.
  9. Górna MW, Carpousis AJ, Luisi BF (2012) From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome. Q Rev Biophys 45:105-45.
  10. Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G (2011) IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 12:624-30.
  11. Goncalves A, Bürckstümmer T, Dixit E, Scheicher R, Górna MW, Karayel E, Sugar C, Stukalov A, Berg T, Kralovics R, Planyavsky M, Bennett KL, Colinge J, Superti-Furga G (2011) Functional dissection of the TBK1 molecular network. PLoS One 6:e23971.
  12. Górna MW, Pietras Z, Tsai YC, Callaghan AJ, Hernández H, Robinson CV, Luisi BF (2010)  The regulatory protein RraA modulates RNA-binding and helicase activities of the E. coli RNA degradosome. RNA 16:553-62.
  13. Worrall JA#, Górna M#, Crump NT, Phillips LG, Tuck AC, Price AJ, Bavro VN, Luisi BF (2008) Reconstitution and analysis of the multi-enzyme Escherichia coli RNA degradosome. J Mol Biol 382:870-883.
  14. Worrall JA, Górna M, Pei XY, Spring DR, Nicholson RL, Luisi BF (2007) Design and chance in the self-assembly of macromolecules. Biochem Soc Trans 35:502-507.              

Selected published conference abstracts:

  1. Papac-Milicevic N, Mohlin FC, Weismann D, Ademi M, Busch CJ, Rebsamen M, Gritti BB, Gorna M, Kiss M, Alic L, Blom AM, Binder CJ (2016) Malondialdehyde epitopes act as hubs for complement activation on dying cells. Immunobiology 221(10):1147-8 (special issue: XXVI ICW Kanazawa 2016)
  2. Byrgazov K, Kastner R, Hoermann G, Gorna M, Koenig M, Hantschel O, Haas O, Valent P, Dworzak M, Urban C, Lion T (2015). NDEL1-PDGFRB fusion gene in juvenile myelomonocytic leukemia associated with resistance to tyrosine kinase inhibitors. Haematologica 100 (Suppl 1):98-9 P304
  3. Górna MW, Vladimer GI, Abbas YM, Gebhardt A, Habjan M, Laudenbach BT, Dimech C, Xie IY, Bennett KL, Nagar B, Pichlmair A, Superti-Furga G (2015). Viral RNA binding by the human IFIT1-IFIT3 protein complex in the innate immune response. Acta Cryst A. A71: s250 (conference issue)
  4. Papac-Milicevic N, Mohlin FC, Weismann D, Busch CJ, Bartolini Gritti B, Gorna MW, Kiss M, Blom AM, Binder CJ (2015). Regulators of complement activity act as scavengers of malondialdehyde adducts - A novel role for C4b-binding protein. Molecular Immunology 67(1), 169-170

 

 #Equal contribution.

  • H-index (Scopus): 9
  • Citations (Scopus) > 500 (excl. autocitations)
  • 5-year IF of the journals > 140

Maria Górna, Ph.D. - current press releases:

Official Opening Ceremony of the Structural Biology Group: Photo Gallery@UW BCRC (July 2016; PL)

EMBO Installation Grant: EMBO website (December 2015; EN):

Grant LIDER:

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Last Updated on Wednesday, 09 August 2017 18:04  


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