Cover Story

First Experimental Quantitative Charge Density Studies of Vitamin D Intermediate

Vitamins D are a group of fat-soluble secosteroids which play a regulatory role in the functioning of most cells. Rational design of new vitamin D analogs of increased therapeutic potency and lowered calcemic side effects requires high-resolution initial structures and a deep understanding of interactions with the vitamin D receptor. In this paper, using quantum crystallography methods, we present the first determination of the experimental quantitative charge density of an advanced intermediate of vitamin D analogues as well as a reconstruction of the theoretical electron density of final vitamin D analogues. Application of these methods allows for topological and electrostatic interaction energy analysis which is important for understanding biological effects.

We are looking for a post-doc !!!

One position for adjunct (post doc) who will develop new models and software in a project at borderline of crystallography and computational chemistry entitled

“Advancing quantum crystallography for better insight into structure and properties of crystals”

financed by National Science Centre (NCN) is open for application.

Project leader: Prof. dr hab. Krzysztof Woźniak

For details see:


Congratulations to our group members because of NCN Grants! We are very excited, because our Group lider, Profesor Krzysztof Woźniak was awarded by OPUS grant, dr Wojciech Sławiński also by OPUS grant, our PhD student Sylwia Pawlędzio by Preludium grant 🙂 Congratulations also goes to dr Mihails Arhangelskis, who won SONATA grant and will start work in our group in October!